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Adamgammadex

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Adamgammadex

Supplied with complete CDSCO-approved import and customs documentation, including Form 12A & 12B, CDEC, GST Bill of Entry, Commercial Invoice, and Packing List.

Medicine Name: Adamgammadex
Generic Name (API): Adamgammadex sodium
Dosage Form & Strength: 250 mg/2 mL
Route: Intravenous (IV) bolus injection
Drug Class: Selective relaxant binding agent (modified γ-cyclodextrin)

Manufacturer / Innovator:

China

Regulatory Approval:

  • NMPA (China)
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    Temperature-controlled logistics ensuring safe, reliable, and timely medicine delivery.

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What Is Adamgammadex Used For?

Adamgammadex is a new injection used at the end of an operation to reverse the muscle relaxant rocuronium, so the patient can breathe on their own again. It was designed by Hangzhou Adamerck Pharmlabs in China and is made by Zhejiang Xianju Pharmaceutical. In China it is sold as 奥美克松® (Aomeikesong), with the Chinese name 阿更葡糖钠注射液.

China's National Medical Products Administration (NMPA) approved it in 2026 (the approval was announced on 2 July 2026) for:

  • Reversal of neuromuscular block caused by rocuronium in adults

It belongs with our medicines for specialist hospital care and is given only by anaesthesia staff in the operating theatre.

How It Works

During many operations, rocuronium is used to relax the muscles. At the end, any drug left behind can leave the patient weak, which can affect breathing. Adamgammadex is a modified ring-shaped sugar molecule (a γ-cyclodextrin). It wraps around rocuronium molecules in the blood, traps them and pulls them away from the muscles, so muscle strength comes back within minutes. Compared with older cyclodextrins, one part of its side chains (the α-carbon) carries an added chiral acetylamino group, which its developers designed to grip rocuronium more firmly.

What the Trials Showed

Two phase 3 trials in China, both published in the British Journal of Anaesthesia, compared it with an established reversal medicine:

  • Moderate block (310 patients, 2024): at 4 mg/kg, 98.7% recovered full muscle strength (train-of-four ratio 0.9) within 5 minutes, against 100% in the comparison group. The median time was 2.25 minutes. Fewer patients had the side effects of special concern (allergic reaction, block coming back, slow heart rate or throat spasm).
  • Deep block (321 patients, 2025): at 8 mg/kg, 98.7% recovered within 10 minutes, against 100%, with a median time of 2.5 minutes. Safety was similar between the groups.

In both trials it met the pre-set standard for working as well as the comparison medicine.

Recommended Dosage

According to the Chinese label, it is given as one quick injection into a vein, completed within 10 seconds:

  • Moderate block (second twitch reappears on train-of-four monitoring): 4 mg per kg
  • Deep block (post-tetanic count of at least 1 to 2): 8 mg per kg
  • The dose is based on actual body weight, including in people with obesity, and is the same in mild or moderate kidney impairment.

Each 2 mL holds 250 mg. As an example, a 70 kg adult needs 280 mg for a moderate block or 560 mg for a deep block. The anaesthetist decides the dose from nerve-stimulator readings.

This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

Warnings and Precautions

Overall safety: across phase 1 to 3 studies, no side effect was very common (10% or more). The common and uncommon ones were all mild or moderate (grade 1 or 2), and there were no serious side effects and no stops because of side effects. No allergic or hypersensitivity reactions and no throat spasm (laryngospasm) were seen with it in the trials.

  • Who should not use it: anyone allergic to the active ingredient or any other ingredient.
  • Allergic reactions and slow heart rate: the label still asks staff to watch for these after the injection.
  • Breathing and block coming back: breathing and muscle function must be monitored until recovery is complete. The breathing tube is removed only when no block is left. If other medicines that deepen muscle block are given after surgery, the block can return.
  • Medicines that can weaken its effect: toremifene, intravenous fusidic acid and hormonal contraceptives can displace rocuronium and are listed as possible interactions.
  • Liver: it is not mainly cleared by the liver; it has not been studied in liver impairment.
  • It is approved for adults only. Safety in pregnancy and breastfeeding has not been established.

How to Access Adamgammadex in India: A 6-Step Process

Step 1 – Search & request your medicine: The patient or treating doctor submits a request with basic details to initiate the access process.

Step 2 – Verification & eligibility review: The team verifies availability and reviews eligibility against regulatory and clinical requirements to ensure a compliant pathway.

Step 3 – Receive quote & delivery timeline: A transparent quotation is shared, covering medicine cost, logistics, and a clear delivery timeline.

Step 4 – Regulatory approval process: Assistance is provided to secure the approvals and documentation required for legal cross-border access.

Step 5 – Temperature-controlled import & handling: The medicine is sourced and transported under strict GDP-compliant conditions to maintain product integrity.

Step 6 – Secure delivery: The medicine is delivered to the patient or treating hospital, with updates provided at each stage.

Note: From request to delivery, every step is designed to ensure your treatment reaches you safely, compliantly, and without unnecessary delays.

Documentation & Availability

What documents are required to import Adamgammadex to India?

The injection can be imported only in the patient's name, by the patient or a government hospital, in line with India's import regulations for unapproved medicines. You will need:

  • A valid prescription from the treating anaesthesiologist
  • Details of the planned surgery, the patient's weight and the hospital
  • Patient ID proof (issued by the Government of India)

How is the order confirmed?

Once we have received and checked a valid prescription and, where needed, an import permit.

Is Adamgammadex available in India?

No. It is approved only in China. It has no CDSCO approval, it is not sold in Indian pharmacies, and the US FDA and European Medicines Agency have not approved it either.

Hospitals can still request it legally through the Named Patient Program (NPP), which allows a medicine not registered in India to be imported for one specific patient on a prescription. Anaesthesia teams may also find our page on Dantrium useful, used in the rare emergency of malignant hyperthermia.

It can be made available to patients, doctors, and hospitals across major cities in India, including Gurgaon, Delhi, Bangalore, Mumbai, Navi Mumbai, Thane, Hyderabad, Mysore, Kerala, Chennai, Coimbatore, Madurai, Kolkata, Ahmedabad, Surat, Vadodara, Pune, Nagpur, Nashik, Jaipur, Udaipur, Lucknow, Kanpur, Gorakhpur, Chandigarh, Mohali, Faridabad, Noida, Ghaziabad, Kochi, Trivandrum, Kozhikode, Thrissur, Kannur, Mangalore, Bhubaneswar, Patna, Ranchi, Raipur, Guwahati, Visakhapatnam, Vijayawada, Goa, Jammu, Srinagar, Dehradun, Bhopal, Indore, Ludhiana, Amritsar, and others — and can facilitate delivery to the patient's treating hospital. Orders are confirmed only after receipt of a valid doctor's prescription and an import permit, where applicable.

Sourcing & Delivery

NamedPatientProgram.com (NPP) sources this medicine through the manufacturer's authorised supply channels in China and arranges supply to doctors and hospitals under applicable legal provisions. The injection travels sealed in its original packs under temperature-controlled shipping and is stored as directed on the pack. Since the dose depends on body weight and on how deep the block is, we help the hospital work out how many packs to keep for the planned operation. All prescriptions are dispensed and checked by registered pharmacists and dispatched from New Delhi, India, after legal requirements are fulfilled.

For the current cost in India and availability, contact NPP via WhatsApp at +91 98104 69557 | Toll-Free: 1800-1200-365 or email info@namedpatientprogram.com.

Availability Across Major Cities in India

Hospitals across India can request this medicine through regulated import pathways, with delivery to the treating hospital on a valid anaesthesiologist's prescription.

Delhi

Large surgical hospitals here can request it for a named patient, and our New Delhi dispatch point keeps transit short.

Mumbai

Supply is timed to the operation date and delivered to the hospital pharmacy.

Bangalore

Anaesthesia departments in Bangalore can send the prescription and the patient's weight to start the import.

Chennai

We work with the hospital pharmacy so the packs and import papers are ready before the surgery day.

Hyderabad

The quote is based on body weight and the expected depth of block, and is shared before anything is ordered.

Kolkata

Deliveries to Kolkata and the eastern states go to the treating hospital with full batch records.

Pune

Hospitals in Pune can use the same documented import route, with updates at each stage.

Ahmedabad

The treating anaesthesiologist can share the planned date so we can plan the quantity.

Vellore

Hospitals in Vellore can have the medicine delivered directly to the operating theatre pharmacy.

Chandigarh

Serves hospitals in Punjab, Haryana and Himachal Pradesh, with delivery to the operating hospital.

Lucknow

We coordinate delivery to public and private hospitals across Uttar Pradesh.

Kochi

Hospitals in Kochi and across Kerala can receive the medicine with the import paperwork in place.

Access can also be coordinated for patients in other Indian cities, subject to a valid prescription and regulatory requirements.

Author Details

Nitin Goswami

Written By

Nitin Goswami

Deputy Manager – Content & Social Media, Ikris Pharma Network

Sources: NMPA • CDSCO

Dr. Chirag C Shah

Medically Reviewed By

Dr. Chirag C Shah

MBBS

Last Updated: 19 October 2026

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