Inrebic

Warnings and Precautions

Boxed warning: encephalopathy, including Wernicke's

Serious brain damage from low thiamine (Wernicke's encephalopathy) has happened with Inrebic: serious cases in 1.3% of patients in the trials, and fatal in 0.16%. This is why thiamine is checked before treatment, low levels are corrected first, and every patient takes daily thiamine. Warning signs are unsteady walking, confusion, memory problems and eye problems such as double vision. If these appear, Inrebic is stopped at once and thiamine is given by injection.

Anaemia and low platelets

New or worse severe anaemia occurred in 34% of patients, usually within the first 3 months, and 51% received a blood transfusion. Severe low platelets occurred in 12%. Blood counts are checked before starting and regularly during treatment.

Stomach and bowel side effects

These are the most common: diarrhoea in 66% of patients, nausea in 62% and vomiting in 39%, usually starting in the first days. The label advises anti-sickness medicine to prevent nausea and treating diarrhoea at the first sign. Thiamine levels are also watched, so tell your doctor if vomiting or diarrhoea does not settle.

Liver and pancreas

Liver enzymes (ALT and AST) rose in about 4 in 10 patients, and severe rises in amylase or lipase were seen in 2% and 10%. These are checked regularly with blood tests.

Eye inflammation (uveitis)

Uveitis was seen in 4% of patients in later studies, usually after more than a year of treatment (median 14 months). Report eye pain, redness or blurred vision.

Heart, clots and other cancers

Another medicine of the same JAK inhibitor class increased the risk of heart attack, stroke, blood clots and some cancers in people with rheumatoid arthritis. Doctors weigh this risk, especially in smokers and people with heart risk factors.

Do not stop suddenly

Myelofibrosis symptoms can flare after stopping a JAK inhibitor. Only stop on your doctor's advice.

Pregnancy and breastfeeding

Animal studies showed harm to the unborn baby, so discuss pregnancy plans with the doctor. Do not breastfeed during treatment and for at least 1 month after the last dose.

This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

How to Get Inrebic in India: Step by Step

Inrebic is not sold in Indian pharmacies, so it is imported for one named patient at a time. One bottle of 120 capsules lasts 30 days at the usual 400 mg dose, so we plan the supply month by month.

Step 1: Share the prescription and reports

Send the prescription with the daily dose, the planned months of treatment, and the latest blood count, as the starting dose depends on the platelet count.

Step 2: Document check

A registered pharmacist checks the prescription, the myelofibrosis diagnosis (bone marrow biopsy, and the JAK2, CALR or MPL report if done) and the patient's ID, and tells you at once if anything is missing.

Step 3: Quote per month

The Inrebic price in India is quoted for the number of bottles needed, plus freight and customs clearance. If the doctor lowers the dose, one bottle lasts longer, and we adjust the next order.

Step 4: Form 12A application and Form 12B permit

We prepare the Form 12A application to CDSCO under Rule 36 of the Drugs and Cosmetics Rules. CDSCO states the Form 12B permit is usually issued within one to two days and stays valid for six months.

Step 5: Import at controlled temperature

Inrebic capsules are stored below 30°C, so they do not need a fridge but must be protected from Indian summer heat in transit.

Step 6: Delivery and refill planning

We deliver to the patient's address on the permit or to the treating hospital, and remind you before the bottle runs out so treatment is not interrupted.

How much time does the process take?

The permit step usually takes one to two working days once all documents are complete. We share the expected delivery date with the quote, as it depends on stock at source and the flight route.

Documents Needed to Import Inrebic

• A prescription that names Inrebic (fedratinib), the daily dose and the number of months, with the doctor's medical council registration number
• Reports that confirm myelofibrosis, such as the bone marrow biopsy and a recent complete blood count
• The thiamine (vitamin B1) test result, which the doctor needs before the first dose
• Patient ID proof issued by the Government of India
• The signed Form 12A, which our team prepares for you

Is Inrebic available in India?

No. Inrebic (fedratinib) has no marketing approval in India and is not sold in Indian pharmacies. We checked the published minutes of CDSCO's oncology and haematology expert committees from 2018 to November 2026, and fedratinib does not appear in them. It can still be imported legally for a named patient under Rule 36, with a Form 12A application and a Form 12B permit.

Fedratinib 100 mg capsules: how many will you need?

Inrebic comes as 100 mg capsules in bottles of 120. At 400 mg a day that is four capsules daily, so one bottle covers 30 days. People often search for the fedratinib 100 mg price, but the monthly cost depends on the dose the haematologist prescribes.

Can you buy Inrebic online in India?

Not from an open online store, because a medicine without Indian approval cannot be sold off the shelf. The legal way is to send the prescription to NPP online, and we arrange the permit and import in the patient's name.

Access from SAARC and Gulf countries

Patients from Nepal, Bangladesh, Bhutan, Sri Lanka and the Gulf can also ask us, subject to each country's import rules. Read our guide to Indian import regulations for the full legal process.

Sourcing & Delivery of Inrebic

Inrebic is made by Celgene, a Bristol Myers Squibb company. As an Inrebic supplier in India under the named patient route, NPP buys it only through authorised channels and only after the patient's permit is issued, so every bottle can be traced to one patient and one prescription.

Storage

Store the capsules below 30°C in the original bottle. Keep them away from hot cars, kitchens and direct sun. We ship in insulated packs that protect against heat; see our temperature-controlled shipping.

Do not forget thiamine

Inrebic must be taken with daily thiamine (vitamin B1) 100 mg. The patient's doctor prescribes the thiamine separately; please make sure it is started before the first Inrebic dose.

Checked before dispatch

A registered pharmacist matches every order with the prescription and the permit before it leaves New Delhi, and checks the expiry date covers the treatment period.

For the Inrebic cost in India and current availability, contact NPP via WhatsApp at +91 98104 69557 | Toll-Free: 1800-1200-365 or email info@namedpatientprogram.com.

Inrebic Access Across Major Cities in India

Inrebic is taken at home, while blood counts and thiamine levels are checked at the haematology clinic. We deliver to the patient or the hospital, as the doctor prefers.

• Delhi NCR: Orders leave from New Delhi, so Delhi, Gurgaon, Noida and Faridabad get the quickest delivery. See imported medicines in Delhi NCR.
• Mumbai: Patients treated by haematologists in Mumbai and Navi Mumbai can receive it at home or at the hospital. See imported medicines in Mumbai.
• Bangalore: Monthly bottles timed to the blood-test visits. See imported medicines in Bangalore.
• Chennai and Vellore: Delivery to the patient or the haematology unit. See imported medicines in Chennai.
• Kolkata: Delivery for patients from eastern India and the North-East. See imported medicines in Kolkata.
• Other cities: Hyderabad, Pune, Ahmedabad, Kerala, Lucknow, Jaipur and more, with delivery to the address on the permit.

See how we arrange delivery of imported medicines to hospitals across India.