What is the generic name of Voraxaze?

The generic name is glucarpidase.

Voraxaze is supplied by BTG International Inc., a SERB company.

What type of medicine is Voraxaze?

It is a recombinant bacterial enzyme (a carboxypeptidase) that breaks down methotrexate.

Is Voraxaze approved by the US FDA?

Yes. It was first approved in the US in 2012. It is also approved in the European Union.

Is Voraxaze approved in India?

No. It has no CDSCO marketing approval and is not sold in India. It can be imported for a named patient with a Form 12B permit.

What strength does Voraxaze come in?

A single-dose vial of 1,000 units of glucarpidase powder.

How is Voraxaze given?

Once, as a 5-minute intravenous injection at 50 units per kg, with leucovorin given at least 2 hours before or after.

Why must methotrexate tests change after Voraxaze?

For 48 hours after Voraxaze, standard immunoassays read methotrexate falsely high, so a chromatographic test should be used.

What are the side effects of Voraxaze?

Tingling, flushing, nausea or vomiting, low blood pressure and headache were reported in more than 1% of patients. Serious allergic reactions occurred in less than 1%.

How fast can Voraxaze reach India?

We start the paperwork the same day you call. The permit usually takes one to two working days, plus the flight. We cannot promise a fixed time, so supportive care must continue meanwhile.

What is the price of Voraxaze in India?

There is no Indian MRP because it is not sold here. The cost depends on body weight (number of vials) and urgent freight. Send the prescription for a written quote.

How can I find a reliable Voraxaze supplier in India?

Choose a supplier that sources only through authorised channels, ships in a monitored cold chain, and gives you the import permit and invoice. NPP works this way for every order.

Is it safe to buy Voraxaze online?

No. It is a hospital emergency medicine. A vial from an unknown website may be fake or may have lost its cold chain.

How should Voraxaze be stored?

In a refrigerator at 2°C to 8°C. Do not freeze.

Where does this information come from?

From the US Voraxaze prescribing information on DailyMed (December 2024) and the EU product information from the European Medicines Agency.

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Voraxaze

Supplied with complete CDSCO-approved import and customs documentation, including Form 12A & 12B, CDEC, GST Bill of Entry, Commercial Invoice, and Packing List.

Medicine Name: Voraxaze

Generic Name (API): Glucarpidase

Dosage Form & Strength: Powder for injection: 1,000 units per vial

Route: Intravenous (IV) injection

Drug Class: Carboxypeptidase enzyme (methotrexate antidote)

Manufacturer / Innovator:

BTG International Inc. (a SERB company)

Regulatory Approval:

US FDA
EMA (Europe)

Prescribing Information Resources

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What Is Voraxaze Used For?

Voraxaze (glucarpidase) is an emergency antidote for methotrexate toxicity. High-dose methotrexate is used for cancers such as osteosarcoma, leukaemia and lymphoma, and it leaves the body through the kidneys. If the kidneys are not working well, methotrexate can stay at toxic levels in the blood.

In the United States, Voraxaze is approved for adults and children whose plasma methotrexate level is toxic (above 1 micromole per litre) and whose clearance is delayed because of impaired kidney function. In the European Union it is approved for adults and children aged 28 days and older with delayed methotrexate elimination or at risk of methotrexate toxicity. It is not used when methotrexate is clearing normally, because lowering the level too much could make the cancer treatment less effective. See our oncology medicines.

How It Works

Glucarpidase is an enzyme. In the bloodstream it breaks methotrexate into inactive pieces, giving the body a way to get rid of methotrexate that does not depend on the kidneys.

What the Study Showed

In the main study, 22 patients with toxic methotrexate levels and kidney problems received Voraxaze. In 10 of them (45%), the methotrexate level fell to 1 micromole per litre or less within 15 minutes and stayed there for up to 8 days. Half of the patients in this group had osteosarcoma, and most of the rest had leukaemia or lymphoma.

Recommended Dosage

The dose is 50 units per kg of body weight, given once as an intravenous injection over 5 minutes. Leucovorin rescue continues, but it must be given at least 2 hours before or after Voraxaze. For the first 48 hours the same leucovorin dose is kept; after that it is adjusted to the measured methotrexate level. Fluids and urine alkalinisation also continue as the doctor directs.

This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

Warnings and Precautions

Serious allergic reactions

Serious hypersensitivity reactions occurred in less than 1% of patients. The care team watches for flushing, rash, breathing difficulty and low blood pressure during and after the injection.

Methotrexate blood tests after Voraxaze

After Voraxaze, an inactive breakdown product of methotrexate (DAMPA) makes standard immunoassay tests show falsely high methotrexate levels for up to 48 hours. During this time, methotrexate should be measured with a chromatographic method. This matters because leucovorin doses are based on these results.

Does not replace other care

Voraxaze is given together with ongoing care: the label says leucovorin rescue continues, along with fluids and urine alkalinisation as needed, guided by methotrexate levels.

Side effects

Side effects linked to Voraxaze itself were uncommon: tingling or numbness, flushing, nausea or vomiting, low blood pressure and headache were each reported in more than 1% of patients. Other problems seen in these patients are usually caused by the methotrexate toxicity itself.

Pregnancy and breastfeeding

There is no information on Voraxaze in pregnancy or breastfeeding. It is always given with methotrexate, whose own strict pregnancy rules apply.

This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

How to Get Voraxaze in India in an Emergency

Voraxaze is not sold in India, so it is imported for one named patient. Because it is an emergency antidote, we treat every Voraxaze request as urgent.

Step 1: Call us immediately

As soon as the treating team sees delayed methotrexate clearance with kidney impairment, the doctor or family should call or WhatsApp us. We start the paperwork the same day.

Step 2: Prescription and documents

We need the prescription with the patient's weight and the number of 1,000-unit vials (for example, a 40 kg patient needs 2,000 units, which is two vials), the latest methotrexate level and kidney test, and the patient's ID.

Step 3: Quote

The Voraxaze price in India is quoted for the vials needed, plus urgent cold-chain freight and customs clearance.

Step 4: Form 12A application and Form 12B permit

We prepare the Form 12A application to CDSCO under Rule 36 of the Drugs and Cosmetics Rules. CDSCO states the Form 12B permit is usually issued within one to two days and stays valid for six months.

Step 5: Urgent cold-chain import

The vials travel at 2°C to 8°C with a temperature logger, on the fastest available route.

Step 6: Delivery to the hospital

We deliver straight to the treating hospital pharmacy.

How fast can it arrive?

We cannot promise a fixed time. The permit usually takes one to two working days once documents are complete, and the flight depends on stock at source. The treating team should continue leucovorin, fluids and kidney support and not wait for the antidote. We tell you the expected arrival time with the quote.

Documents Needed to Import Voraxaze

A prescription that names Voraxaze (glucarpidase), the dose in units, the patient's weight and the number of vials, with the doctor's medical council registration number
A short medical note with the methotrexate dose and timing, the latest plasma methotrexate level and the kidney function test
Patient ID proof issued by the Government of India (for a child, also the parent's ID)
The signed Form 12A, which our team prepares for you

Is Voraxaze available in India?

No. Voraxaze (glucarpidase) has no marketing approval in India and is not sold in Indian pharmacies. We checked the published minutes of CDSCO's oncology and haematology expert committees from 2018 to November 2026, and glucarpidase does not appear in them. It can still be imported legally for a named patient under Rule 36, with a Form 12A application and a Form 12B permit.

Voraxaze 1,000 units: how many vials are needed?

Each vial contains 1,000 units of glucarpidase powder. The dose is 50 units/kg, so the number of vials depends on weight: 1 vial covers up to 20 kg, 2 vials up to 40 kg, and so on. People often search for the glucarpidase price, but the cost depends on the number of vials.

Can you buy Voraxaze online in India?

No. It is a hospital emergency medicine and cannot be sold off the shelf. The legal way is to send the prescription to NPP, and we arrange the permit and import in the patient's name.

Access from SAARC and Gulf countries

Patients from Nepal, Bangladesh, Bhutan, Sri Lanka and the Gulf can also ask us, subject to each country's import rules. Read our guide to Indian import regulations for the full legal process.

Sourcing & Delivery of Voraxaze

Voraxaze is supplied by BTG International, a SERB company. As a Voraxaze supplier in India under the named patient route, NPP buys it only through authorised channels and only after the patient's permit is issued, so every vial can be traced to one patient and one prescription.

Cold storage

Vials must be kept in a refrigerator at 2°C to 8°C and must not be frozen. We ship in validated insulated boxes with a data logger and check the temperature record on arrival. Read more about our temperature-controlled shipping.

At the hospital

The hospital pharmacy dissolves each vial in 1 mL of saline, without shaking, and gives it as a 5-minute injection, flushing the line before and after.

Checked before dispatch

A registered pharmacist matches every order with the prescription and the permit before it leaves New Delhi.

For the Voraxaze cost in India and current availability, contact NPP via WhatsApp at +91 98104 69557 | Toll-Free: 1800-1200-365 or email info@namedpatientprogram.com.

Voraxaze Access Across Major Cities in India

Voraxaze is given in hospital, usually in oncology wards that use high-dose methotrexate, so we deliver straight to the treating hospital by the fastest cold-chain route.

Delhi NCR: Orders are handled from New Delhi, so hospitals in Delhi, Gurgaon, Noida and Faridabad are closest. See imported medicines in Delhi NCR.
Mumbai: Delivery to cancer hospitals in Mumbai and Navi Mumbai. See imported medicines in Mumbai.
Bangalore: Direct hospital delivery. See imported medicines in Bangalore.
Chennai and Vellore: Direct hospital delivery. See imported medicines in Chennai.
Kolkata: Delivery for patients from eastern India and the North-East. See imported medicines in Kolkata.
Other cities: Hyderabad, Pune, Ahmedabad, Kerala, Lucknow, Jaipur and more, by the fastest air cold chain.