Margenza

Warnings and Precautions

Boxed warning: heart function

Margenza can weaken the heart's pumping power (left ventricular ejection fraction, LVEF). In SOPHIA this happened in 1.9% of patients. An echocardiogram or MUGA scan is needed within 4 weeks before starting and every 3 months during treatment. Treatment is paused if LVEF drops by a set amount, and stopped for good if it does not recover within 8 weeks. It has not been studied in people with LVEF below 50%, a recent heart attack or heart failure. Report breathlessness, swollen ankles, a racing heart or sudden weight gain.

Boxed warning: harm to an unborn baby

HER2 antibodies used during pregnancy have caused too little amniotic fluid, poor lung and bone development and death of the newborn. A pregnancy test is done before starting. Women who can become pregnant should use effective contraception during treatment and for 4 months after the last dose.

Infusion reactions

Infusion reactions occurred in 13% of patients, mostly in the first cycle, and were severe in 1.5%. Signs include fever, chills, cough, dizziness, rash, a fast heartbeat and low blood pressure. All resolved within 24 hours. The nurse slows or stops the infusion if a reaction happens.

Other common side effects

With chemotherapy, the most common side effects were tiredness, nausea, diarrhoea, vomiting, constipation, headache, fever, hair loss, stomach pain, numbness or tingling (neuropathy), joint and muscle pain, cough, loss of appetite, breathlessness and redness or peeling on the palms and soles. Many of these come from the chemotherapy given with it. This is not a complete list.

This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

How to Get Margenza in India: Step by Step

Margenza is not sold in Indian pharmacies, so every order is arranged for one named patient. As it is given every 3 weeks, we plan the supply cycle by cycle.

Step 1: Share the treatment plan

Send the prescription with the chemotherapy it will be given with, the patient's current weight and the planned number of cycles. The dose is 15 mg/kg, so a 60 kg patient needs 900 mg per infusion, which means four 250 mg vials. Our pharmacist confirms the vial count for each cycle.

Step 2: Document check

A registered pharmacist checks the prescription, the HER2-positive report, the list of earlier HER2 treatments and the patient's ID, and tells you at once if anything is missing.

Step 3: Quote per cycle

The Margenza price in India is quoted for the vials needed per 3-week cycle, plus cold-chain freight and customs clearance.

Step 4: Form 12A application and Form 12B permit

We prepare the Form 12A application to CDSCO under Rule 36 of the Drugs and Cosmetics Rules. CDSCO states the Form 12B permit is usually issued within one to two days and stays valid for six months.

Step 5: Cold-chain import

The vials travel at 2°C to 8°C in their original cartons, with a temperature logger in every box.

Step 6: Delivery before each infusion

We deliver to the hospital pharmacy or day-care unit, timed to the chemotherapy day.

How much time does the process take?

The permit step usually takes one to two working days once all documents are complete. We share the expected delivery date with the quote, as it depends on stock at source and the flight route.

Documents Needed to Import Margenza

• A prescription that names Margenza (margetuximab), the dose, the chemotherapy it is given with, the number of vials and cycles, with the doctor's medical council registration number
• The pathology report showing HER2-positive breast cancer (IHC 3+ or ISH-amplified)
• A summary of earlier HER2 treatments and a recent echocardiogram or MUGA report
• Patient ID proof issued by the Government of India
• The signed Form 12A, which our team prepares for you

Is Margenza available in India?

No. Margenza (margetuximab) has no marketing approval in India and is not sold in Indian pharmacies. We checked the published minutes of CDSCO's oncology and haematology expert committees from 2018 to November 2026, and margetuximab does not appear in them. It is also not authorised in the European Union, so supply comes from the United States. It can still be imported legally for a named patient under Rule 36, with a Form 12A application and a Form 12B permit.

Margenza 250 mg vial: how many will you need?

Margenza comes as a 250 mg/10 mL single-dose vial, in cartons of one or four. The number of vials per cycle depends on body weight. People often search for the margetuximab 250 mg price, but the cycle cost depends on weight and the number of cycles.

Can you buy Margenza online in India?

Not from an open online store, because a medicine without Indian approval cannot be sold off the shelf. The legal way is to send the prescription to NPP online, and we arrange the permit and import in the patient's name.

Access from SAARC and Gulf countries

Patients from Nepal, Bangladesh, Bhutan, Sri Lanka and the Gulf can also ask us, subject to each country's import rules. Read our guide to Indian import regulations for the full legal process.

Sourcing & Delivery of Margenza

Margenza is made by TerSera Therapeutics in the United States. As a Margenza supplier in India under the named patient route, NPP buys it only through authorised channels and only after the patient's permit is issued, so every vial can be traced to one patient and one prescription.

Cold storage

Unopened vials must be kept in a refrigerator at 2°C to 8°C, in the original carton to protect them from light. They must not be frozen or shaken. We ship in validated insulated boxes with a data logger and check the temperature record on arrival. Read more about our temperature-controlled shipping.

At the hospital

The hospital pharmacy dilutes the vials in a saline bag just before use. Per the US label, the prepared bag can be kept for up to 4 hours at room temperature or up to 24 hours in the fridge. This is why we time each delivery close to the infusion day.

Checked before dispatch

A registered pharmacist matches every order with the prescription and the permit before it leaves New Delhi.

For the Margenza cost in India and current availability, contact NPP via WhatsApp at +91 98104 69557 | Toll-Free: 1800-1200-365 or email info@namedpatientprogram.com.

Margenza Access Across Major Cities in India

Margenza is given in hospital oncology day-care units, so we deliver to the hospital where the patient has chemotherapy, timed to each 3-week cycle.

• Delhi NCR: Orders leave from New Delhi, so hospitals in Delhi, Gurgaon, Noida and Faridabad have the shortest cold-chain route. See imported medicines in Delhi NCR.
• Mumbai: Breast cancer patients treated in Mumbai and Navi Mumbai can receive it at their hospital pharmacy. See imported medicines in Mumbai.
• Bangalore: Delivery to the treating hospital, planned around the infusion calendar. See imported medicines in Bangalore.
• Chennai: Cold-chain delivery to the oncology unit. See imported medicines in Chennai.
• Kolkata: Delivery for patients from eastern India and the North-East. See imported medicines in Kolkata.
• Other cities: Hyderabad, Pune, Ahmedabad, Kerala, Lucknow, Jaipur and more, by air cold chain to the hospital pharmacy.

See how we arrange delivery of imported medicines to hospitals across India.