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Melanoma & Skin Cancer

Melanoma and Skin Cancer Medicines in India: Imported Options by Type

Written by Nitin Goswami Medically reviewed by Dr. Chirag C Shah Last updated
QUICK ANSWERMelanoma is uncommon in India, with an estimated 4,074 new cases in 2024, but it is often deadly here: 1,553 people died of it in the same year [1]. Many Indian patients have melanoma that started inside the body, such as in the rectum, rather than on the skin [3]. When melanoma cannot be operated on or has already reached other organs, and in advanced basal cell, squamous cell or skin lymphoma, newer medicines cleared by the US FDA or China's NMPA may help, yet Indian pharmacies do not keep them. Through Named Patient Program (NPP), 15 of these can be imported for one patient at a time on an oncologist's prescription.
4,074
new melanoma cases in India in 2024 – 0.26% of all cancers diagnosed in the country
Source: IARC GLOBOCAN 2024 [1]
38 in 100
deaths per 100 new melanoma cases in India in 2024 (1,553 ÷ 4,074), against 17 in 100 worldwide (58,398 ÷ 3,37,969)
Source: IARC GLOBOCAN 2024 [1, 2]
59%
of advanced melanoma patients treated at a Kolkata cancer centre had mucosal melanoma, most often in the anorectum
Source: Tata Medical Center study, 185 patients [3]
30%
of 70 Indian melanoma samples carried the BRAF V600E change that BRAF tablets act on
Source: Indian pyrosequencing study [4]

Four kinds of skin cancer, four different sets of medicines

"Skin cancer" covers diseases that behave very differently. Basal cell and squamous cell carcinoma grow from the top layer of the skin and are usually cured by removing them. Melanoma grows from pigment cells and is more likely to spread. Skin lymphoma is a cancer of white blood cells that shows up as patches or lumps on the skin. The medicines on this page are mostly for the smaller group of patients whose cancer has spread, has come back, or cannot be treated with surgery or radiation.

TypeWhere it startsWhen medicines are usedMedicine groups on this page
MelanomaPigment cells (melanocytes) in the skin, or in the lining of the mouth, nose, rectum or genital tract (mucosal melanoma)Cannot be removed, has spread, or after surgery when the risk of return is highImmunotherapy (PD-1, PD-1 + LAG-3), BRAF + MEK pairs, an NRAS-targeted MEK inhibitor
Basal cell carcinoma (BCC)Base of the outer skin layer, often on the faceLocally advanced or spread, when surgery or radiation is not suitableHedgehog pathway inhibitors, then PD-1 immunotherapy
Cutaneous squamous cell carcinoma (CSCC)Flat cells of the outer skin layerLocally advanced or spread, or after surgery and radiation when the risk of return is highPD-1 immunotherapy
Skin lymphoma (CTCL)T-cells, a type of white blood cell, that settle in the skin (mycosis fungoides, Sézary syndrome)Disease that persists or returns after earlier whole-body treatmentCCR4 antibody, HDAC inhibitors, a retinoid capsule

GLOBOCAN does not list basal cell and squamous cell cancer separately for India. The gap between its two national totals (all cancers 15,62,581; all cancers excluding non-melanoma skin cancer 15,48,902) puts them at about 13,679 cases in 2024 [1]. An Indian review notes that there is no national survey of skin cancer types in India [5].

Melanoma in India often does not start on the skin

Most melanoma information online is written for fair-skinned populations, where melanoma usually begins as a changing mole. Indian hospital data look different. Tata Medical Center in Kolkata reviewed 460 melanoma patients treated between 2013 and 2020 [3]:

  • 185 of them (42%) already had cancer that had spread when they were first seen.
  • Among these 185, mucosal melanoma (59%) was more common than skin melanoma (38%), and the anorectum was the single most common starting point (45%).
  • Only 65 had a tumour gene test, and a BRAF change was found in 12 of them.
  • Only 59 patients (32%) received any medicine treatment for advanced disease, and just 17 received immunotherapy, the one factor linked with longer control of the cancer in that study.

Two practical points follow. First, ask whether the tumour has been tested for BRAF, and for NRAS if BRAF is negative, because the result decides which tablets can be used. Second, immunotherapy is approved for melanoma that cannot be removed or has spread, without limiting it to melanoma of the skin; your oncologist decides whether it suits a mucosal melanoma.

Imported melanoma and skin cancer medicines by type

All 15 medicines below are prescription-only. Tap a type to filter. Each card opens the full medicine page with dosage, storage and safety details.

Opdivo (nivolumab)
Opdivo
nivolumab · IV infusion
Unresectable or metastatic melanoma, alone or with ipilimumab; and after complete removal of stage IIB–IV melanoma (age 12+)
Melanoma US FDA
Opdualag (nivolumab + relatlimab)
Opdualag
nivolumab + relatlimab · IV infusion
Unresectable or metastatic melanoma in adults and children aged 12 and above
Melanoma US FDA
Tafinlar (dabrafenib)
Tafinlar
dabrafenib · Capsule
BRAF V600E melanoma alone; with Mekinist for V600E/V600K advanced melanoma and after surgery when lymph nodes were involved
MelanomaBRAF US FDA
Mekinist (trametinib)
Mekinist
trametinib · Tablet
BRAF V600E/V600K melanoma, alone (if no earlier BRAF inhibitor) or with Tafinlar, including after surgery
MelanomaBRAF US FDA
Braftovi (encorafenib)
Braftovi
encorafenib · Capsule
With Mektovi for unresectable or metastatic BRAF V600E/V600K melanoma
MelanomaBRAF US FDA
Mektovi (binimetinib)
Mektovi
binimetinib · Tablet
With Braftovi for unresectable or metastatic BRAF V600E/V600K melanoma
MelanomaBRAF US FDA
Zelboraf (vemurafenib)
Zelboraf
vemurafenib · Tablet
Unresectable or metastatic melanoma with BRAF V600E
MelanomaBRAF US FDA
Tunlametinib (tunlametinib)
Tunlametinib
tunlametinib · Capsule
Advanced NRAS-mutant melanoma after PD-1 or PD-L1 immunotherapy (conditional approval)
MelanomaNRAS China NMPA
Erivedge (vismodegib)
Erivedge
vismodegib · Capsule
Metastatic BCC, or locally advanced BCC not suitable for surgery and radiation
Basal cell US FDA
Odomzo (sonidegib)
Odomzo
sonidegib · Capsule
Locally advanced BCC that returned after, or is not suitable for, surgery or radiation
Basal cell US FDA
Libtayo (cemiplimab)
Libtayo
cemiplimab · IV infusion
Advanced CSCC, high-risk CSCC after surgery and radiation, and advanced BCC after a hedgehog inhibitor or when one is not suitable
Basal cellSquamous cell US FDA
Poteligeo (mogamulizumab)
Poteligeo
mogamulizumab · IV infusion
Relapsed or refractory mycosis fungoides or Sézary syndrome after one earlier systemic therapy
Skin lymphoma (CTCL) US FDA
Istodax (romidepsin)
Istodax
romidepsin · IV infusion
CTCL in adults after at least one earlier systemic therapy
Skin lymphoma (CTCL) US FDA
Zolinza (vorinostat)
Zolinza
vorinostat · Capsule
Skin signs of CTCL that persist or return on or after two systemic therapies
Skin lymphoma (CTCL) US FDA
Targretin (bexarotene)
Targretin
bexarotene · Capsule
Skin signs of CTCL not controlled by at least one earlier systemic therapy
Skin lymphoma (CTCL) US FDA

Compare all 15 melanoma and skin cancer medicines

MedicineGeneric nameMelanoma and skin cancer typeFormApproved by
OpdivonivolumabMelanomaIV infusionUS FDA
Opdualagnivolumab + relatlimabMelanomaIV infusionUS FDA
TafinlardabrafenibMelanoma, BRAFCapsuleUS FDA
MekinisttrametinibMelanoma, BRAFTabletUS FDA
BraftoviencorafenibMelanoma, BRAFCapsuleUS FDA
MektovibinimetinibMelanoma, BRAFTabletUS FDA
ZelborafvemurafenibMelanoma, BRAFTabletUS FDA
TunlametinibtunlametinibMelanoma, NRASCapsuleChina NMPA
ErivedgevismodegibBasal cellCapsuleUS FDA
OdomzosonidegibBasal cellCapsuleUS FDA
LibtayocemiplimabBasal cell, Squamous cellIV infusionUS FDA
PoteligeomogamulizumabSkin lymphoma (CTCL)IV infusionUS FDA
IstodaxromidepsinSkin lymphoma (CTCL)IV infusionUS FDA
ZolinzavorinostatSkin lymphoma (CTCL)CapsuleUS FDA
TargretinbexaroteneSkin lymphoma (CTCL)CapsuleUS FDA

Reports your oncologist will look at

For several of these medicines, the approval depends on a specific test result, so the report usually comes before the prescription.

Test or reportWhy it mattersMedicines linked to it
BRAF V600 test on the tumourV600E and V600K are different changes. Zelboraf, and Tafinlar on its own, are approved for V600E only; the tablet pairs are approved for V600E or V600KTafinlar + Mekinist, Braftovi + Mektovi, Zelboraf
NRAS mutation testNeeded before an NRAS-targeted MEK inhibitorTunlametinib
Stage and surgery reportOpdivo and the Tafinlar + Mekinist pair are also approved after complete removal of melanoma, at specific stagesOpdivo, Tafinlar + Mekinist
Surgery and radiation historyThe BCC and CSCC approvals apply when surgery or radiation is not suitable, or after them in high-risk CSCCErivedge, Odomzo, Libtayo
Earlier hedgehog inhibitor treatmentLibtayo is approved for advanced BCC after a hedgehog inhibitor, or when one is not appropriateLibtayo
Skin biopsy and blood test for CTCLConfirms mycosis fungoides or Sézary syndrome and shows earlier treatmentsPoteligeo, Istodax, Zolinza, Targretin

Import papers, hospital delivery and paying for treatment

Each medicine here is brought in for one named patient. The patient applies to CDSCO on Form 12A, which our pharmacist prepares in the patient's name, and CDSCO then issues a Form 12B permit; our step-by-step Form 12A/12B guide lists the papers. Opdivo, Opdualag, Libtayo, Poteligeo and Istodax are infusions given in hospital, so we can send them straight to the treating hospital through our temperature-controlled hospital delivery.

Immunotherapy and targeted tablets are often taken for a year or longer. Our page on patient support and access programs explains which manufacturer programs, government schemes and charities may help with the cost.

How to get these melanoma and skin cancer medicines in India

1

Prescription
Your oncologist prescribes the medicine.

2

Share documents
Send the prescription and latest reports through Online Order.

3

Import paperwork
Our team checks the source and the import permissions.

4

Delivery
Delivered with the right storage, including cold chain.

Read How to Order and Indian import regulations. We also serve patients in Delhi NCR, Bangalore, Chennai, Mumbai, Kolkata and Hyderabad.

Has your oncologist prescribed one of these medicines?

Share the prescription and we will guide you on availability and next steps.

Online Order

Read more about melanoma and skin cancer

References

  1. IARC Global Cancer Observatory. GLOBOCAN 2024 – India fact sheet (September 2026). https://gco.iarc.who.int/media/globocan/factsheets/populations/356-india-fact-sheet.pdf
  2. IARC Global Cancer Observatory. GLOBOCAN 2024 – Melanoma of skin fact sheet (July 2026). https://gco.iarc.who.int/media/globocan/factsheets/cancers/16-melanoma-of-skin-fact-sheet.pdf
  3. Biswas B et al. Not so 'rare' – an example of malignant melanoma in India: report from a tertiary cancer centre. Ecancermedicalscience. 2021;15:1335. https://pubmed.ncbi.nlm.nih.gov/35211204/
  4. Ahmad F et al. Molecular evaluation of BRAF V600 mutation in Indian malignant melanoma patients. Cancer Genet. 2019;231-232:46-53. https://pubmed.ncbi.nlm.nih.gov/30803557/
  5. Panda S. Nonmelanoma skin cancer in India: current scenario. Indian J Dermatol. 2010;55(4):373-8. https://pubmed.ncbi.nlm.nih.gov/21430894/
  6. US FDA prescribing information for each US-approved medicine (DailyMed). https://dailymed.nlm.nih.gov/dailymed/

This page gives general information only and does not replace medical advice. All medicines listed are prescription-only and must be used under a qualified oncologist.

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